Resumen
La industria de la confitería está en constante crecimiento e innovación debido a la alta demanda de dulces y productos a base de cereales, especialmente entre los niños. Los dulces tradicionales y gourmet, elaborados de granos, semillas y cereales como cacao, maíz, arroz, trigo, cacahuate, almendras, nueces, avellanas, pistaches y productos lácteos, son muy susceptibles a contaminarse con micotoxinas. Debido a los procesos de producción artesanal, es difícil eliminar la contaminación química y por toxinas. Es bien sabido que las micotoxinas son agentes cancerígenos potenciales, que pueden representar un grave problema de salud pública, especialmente para los niños. Esta revisión tiene como objetivo capturar y discutir el estado del arte en la identificación y evaluación de la exposición a micotoxinas en dulces, confitería y productos procesados a base de cereales en todo el mundo. También destaca metodologías novedosas para su evaluación y resume las tendencias pasadas, actuales y futuras. Por último, muestra la relevancia del establecimiento de regulaciones estrictas de sanidad y el monitoreo constante de la contaminación por micotoxinas en industrias alimenticias.
Citas
Abdallah, M. F., Krska, R., & Sulyok, M. (2018). Occurrence of ochratoxins, fumonisin B2, aflatoxins (B1 and B2), and other secondary fungal metabolites in dried date palm fruits from Egypt: a mini‐survey. Journal of Food Science, 83(2), 559-564. https://doi.org/10.1111/1750-3841.14046
Adaku-Chilaka, C., & Mally, A. (2020). Mycotoxin Occurrence, Exposure and Health Implications in Infants and Young Children in Sub-Saharan Africa: A Review. Foods, 9(11). https://doi.org/10.3390/foods9111585
Adebiyi, J. A., Kayitesi, E., Adebo, O. A., Changwa, R., & Njobeh, P. B. (2019). Food fermentation and mycotoxin detoxification: An African perspective. Food Control, 106, 106731. https://doi.org/10.1016/j.foodcont.2019.106731
Afsah‐Hejri, L., Jinap, S., Hajeb, P., Radu, S., & Shakibazadeh, S. (2013). A review on mycotoxins in food and feed: Malaysia case study. Comprehensive Reviews in Food Science and Food Safety, 12(6), 629-651. https://doi.org/10.1111/1541-4337.12029
Agriopoulou, S., Stamatelopoulou, E., & Varzakas, T. (2020). Advances in occurrence, importance, and mycotoxin control strategies: Prevention and detoxification in foods. Foods, 9(2), 137. https://doi.org/10.3390/foods9020137
Ahmed Adam, M. A., Tabana, Y. M., Musa, K. B., & Sandai, D. A. (2017). Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review). Oncology Reports, 37(3), 1321-1336. https://doi.org/10.3892/or.2017.5424
Alassane-Kpembi, I., Puel, O., Pinton, P., Cossalter, A. M., Chou, T. C., & Oswald, I. P. (2017). Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants. Archives of Toxicology, 91(7), 2677-2687. https://doi.org/10.1007/s00204-016-1902-9
Alberts, J., Lilly, M., Rheeder, J., Burger, H.-M., Shephard, G. S., & Gelderblom, W. (2017). Technological and community-based methods to reduce mycotoxin exposure. Food Control, 73, 101-109. https://doi.org/10.1016/j.foodcont.2016.05.029
Alexandre, A. P. S., Castanha, N., Costa, N. S., Santos, A. S., Badiale‐Furlong, E., Augusto, P. E. D., & Calori‐Domingues, M. A. (2019). Ozone technology to reduce zearalenone contamination in whole maize flour: Degradation kinetics and impact on quality. Journal of the Science of Food and Agriculture, 99(15), 6814-6821. https://doi.org/10.1002/jsfa.9966
Alshannaq, A., & Yu, J.-H. (2017). Occurrence, toxicity, and analysis of major mycotoxins in food. International journal of environmental research and public health, 14(6), 632. https://doi.org/10.3390/ijerph14060632
Amri, E., & Lenoi, S. o. (2016). Aflatoxin and fumonisin contamination of sun-dried sweet potato (Ipomoea batatas L.) chips in Kahama district, Tanzania. Journal of Applied & Environmental Microbiology. https://doi.org/10.12691/jaem-4-3-2
Andrade, P. D., Dias, J. V., Souza, D. M., Brito, A. P., van Donkersgoed, G., Pizzutti, I. R., & Caldas, E. D. (2020). Mycotoxins in cereals and cereal-based products: Incidence and probabilistic dietary risk assessment for the Brazilian population. Food and Chemical Toxicology, 143, 111572. https://doi.org/10.1016/j.fct.2020.111572
Arce-López, B., Lizarraga, E., López de Mesa, R., & González-Peñas, E. (2021). Assessment of Exposure to Mycotoxins in Spanish Children through the Analysis of Their Levels in Plasma Samples. Toxins, 13(2), 150. https://doi.org/10.3390/toxins13020150
Arrúa, A. A., Mendes, J. M., Arrúa, P., Ferreira, F. P., Caballero, G., Cazal, C.,... Fernández Ríos, D. (2019). Occurrence of Deoxynivalenol and Ochratoxin A in Beers and Wines Commercialized in Paraguay. Toxins, 11(6). https://doi.org/10.3390/toxins11060308
Ayelign, A., & De Saeger, S. (2020). Mycotoxins in Ethiopia: Current status, implications to food safety and mitigation strategies. Food Control, 113, 107163. https://doi.org/10.1016/j.foodcont.2020.107163
Ayeni, K. I., Sulyok, M., Krska, R., Warth, B., & Ezekiel, C. N. (2023). Mycotoxins in complementary foods consumed by infants and young children within the first 18 months of life. Food Control, 144, 109328. https://doi.org/10.1016/j.foodcont.2022.109328
Azam, M., Ahmed, S., Islam, M., Maitra, P., & Yu, D. (2021). Critical Assessment of Mycotoxins in Beverages and Their Control Measures. Toxins, 13(5), 323. https://doi.org/10.3390/toxins13050323
Bbosa, G. S., Kitya, D., Lubega, A., Ogwal-Okeng, J., Anokbonggo, W. W., & Kyegombe, D. B. (2013). Review of the Biological and Health Effects of Aflatoxins on Body Organs and Body Systems. In R.-A. M (Ed.), Aflatoxins - Recent Advances and Future Prospects. https://doi.org/https://doi.org/10.5772/51201
Bezerra da Rocha, M. E., Oliveira, F., Francisco da Chagas , Feitosa, M. F. E., Florindo, G. M. I., & Rondina, D. (2014). Mycotoxins and Their Effects on Human and Animal Health. Food Control, 36(1), 159-165. https://doi.org/10.1016/j.foodcont.2013.08.021
Binder, E., Tan, L., Chin, L., Handl, J., & Richard, J. (2007). Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Animal Feed Science and Technology, 137(3-4), 265-282. https://doi.org/10.1016/j.anifeedsci.2007.06.005
Blankson, G. K., & Mill-Robertson, F. C. (2016). Aflatoxin contamination and exposure in processed cereal-based complementary foods for infants and young children in Greater Accra, Ghana. Food Control, 64, 212-217. https://doi.org/10.1016/j.foodcont.2015.12.032
Boevre, M., Diana Di Mavungu, J., Landschoot, S., Audenaert, K., Eeckhout, M., Maene, P.,... Saeger, S. (2012). Natural occurrence of mycotoxins and their masked forms in food and feed products. World Mycotoxin Journal, 5, 207-219. https://doi.org/10.3920/WMJ2012.1410
Braun, M. S., & Wink, M. (2018). Exposure, occurrence, and chemistry of fumonisins and their cryptic derivatives. Comprehensive reviews in food science and food safety, 17(3), 769-791. https://doi.org/10.1111/1541-4337.12334
Brera, C., Debegnach, F., De Santis, B., Iafrate, E., Pannunzi, E., Berdini, C.,... Miraglia, M. (2011). Ochratoxin A in cocoa and chocolate products from the Italian market: occurrence and exposure assessment. Food Control, 22(10), 1663-1667. https://doi.org/10.1016/j.foodcont.2011.03.026
Cabrera-Meraz, J., Maldonado, L., Bianchini, A., & Espinal, R. (2021). Incidence of aflatoxins and fumonisins in grain, masa and corn tortillas in four municipalities in the department of Lempira, Honduras. Heliyon, 7(12), e08506. https://doi.org/10.1016/j.heliyon.2021.e08506
Cendoya, E., del Pilar Monge, M., Chiacchiera, S. M., Farnochi, M. C., & Ramirez, M. L. (2018). Influence of water activity and temperature on growth and fumonisin production by Fusarium proliferatum strains on irradiated wheat grains. International Journal of Food Microbiology, 266, 158-166. https://doi.org/10.1016/j.ijfoodmicro.2017.12.001
Cheli, F., Battaglia, D., Gallo, R., & Dell'Orto, V. (2014). EU legislation on cereal safety: An update with a focus on mycotoxins. Food Control, 37, 315-325. https://doi.org/10.1016/j.foodcont.2013.09.059
Chen, L., Wu, J., Zhang, S., Liu, X., Zhao, M., Guo, W., Zhang, J., Chen, W., Liu, Z., Deng, M., & Wu, Q. (2025). Occurrence and Diversity of Fungi and Their Mycotoxin Production in Common Edible and Medicinal Substances from China. Journal of Fungi, 11(3), 212. https://doi.org/10.3390/jof11030212
Chen, M.-T., Hsu, Y.-H., Wang, T.-S., & Chien, S.-W. (2016). Mycotoxin Monitoring for Commercial Foodstuffs in Taiwan. Journal of Food and Drug Analysis, 24(1), 147-156. https://doi.org/10.1016/j.jfda.2015.06.002
Copetti, M. V., Iamanaka, B. T., Nester, M. A., Efraim, P., & Taniwaki, M. H. (2013). Occurrence of ochratoxin A in cocoa by-products and determination of its reduction during chocolate manufacture. Food Chemistry, 136(1), 100-104. https://doi.org/10.1016/j.foodchem.2012.07.093
Copetti, M. V., Iamanaka, B. T., Pitt, J. I., & Taniwaki, M. H. (2014). Fungi and mycotoxins in cocoa: From farm to chocolate. International Journal of Food Microbiology, 178, 13-20. https://doi.org/10.1016/j.ijfoodmicro.2014.02.023
Copetti, M. V., Pereira, J. L., Iamanaka, B. T., Pitt, J. I., & Taniwaki, M. H. (2010). Ochratoxigenic fungi and ochratoxin A in cocoa during farm processing. International Journal of Food Microbiology, 143(1-2), 67-70. https://doi.org/10.1016/j.ijfoodmicro.2010.07.031
da Silva, A.R., Pomini, T.M., Cancian, M.A.Q., Ono, E.Y.S., Maciel, L.F., & Hirooka, .Y. (2024). Aflatoxin and microbial safety in commercial confectionery peanut paçoca produced in São Paulo state – Brazil. Food Control, 164, 110576. https://doi.org/10.1016/j.foodcont.2024.110576
de Cesare, G., Nascetti, A., Scipinotti, R., Fanelli, C., Ricelli, A., & Caputo, D. (2018). Optoelectronic system for mycotoxin detection in food quality control. IEEE Transactions on Components, Packaging and Manufacturing Technology, 8(7), 1195-1202. https://doi.org/10.1109/TCPMT.2018.2823868
De Girolamo, A., Lattanzio, V. M., Schena, R., Visconti, A., & Pascale, M. (2014). Use of liquid chromatography-high-resolution mass spectrometry for isolation and characterization of hydrolyzed fumonisins and relevant analysis in maize-based products. Journal of Mass Spectrometry, 49(4), 297-305. https://doi.org/10.1002/jms.3342
De Santis, B., Brera, C., Mezzelani, A., Soricelli, S., Ciceri, F., Moretti, G., . . . Raggi, M. E. (2019). Role of mycotoxins in the pathobiology of autism: A first evidence. Nutritional Neuroscience, 22(2), 132-144. https://doi.org/10.1080/1028415x.2017.1357793
Di Salvo, E., Bartolomeo, G., Vadala, R., Costa, R., & Cicero, N. (2025). Mycotoxins in Ready-to-Eat Foods: Regulatory Challenges and Modern Detection Methods. Toxics, 13(6), 485. https://doi.org/10.3390/toxics13060485
Dzuman, Z., Vaclavikova, M., Polisenska, I., Veprikova, Z., Fenclova, M., Zachariasova, M., & Hajslova, J. (2014). Enzyme-linked immunosorbent assay in analysis of deoxynivalenol: investigation of the impact of sample matrix on results accuracy. Analytical and bioanalytical chemistry, 406(2), 505-514. https://doi.org/10.1007/s00216-013-7463-3
El-Sayed, R. A., Jebur, A. B., Kang, W., & El-Demerdash, F. M. (2022). An overview of the major mycotoxins in food products: characteristics, toxicity, and analysis. Journal of Future Foods, 2(2), 91-102. https://doi.org/10.1016/j.jfutfo.2022.03.002
Embaby, E., Reda, M., Abdel-Wahhab, M. A., Omara, H., & Mokabel, A. M. (2013). Occurrence of toxigenic fungi and mycotoxins in some legume seeds. Journal of Agricultural Technology, 9(1), 151-164.
FAO, Organization, W. H., & Additives, W. E. C. o. F. (2017). Evaluation of certain contaminants in food: eighty-third report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization.
Fernández-Cruz, M. L., Mansilla, M. L., & Tadeo, J. L. (2010). Mycotoxins in fruits and their processed products: Analysis, occurrence and health implications. Journal of Advanced Research, 1(2), 113-122. https://doi.org/10.1016/j.jare.2010.03.002
Flores-Flores, M. E., Lizarraga, E., López de Cerain, A., & González-Peñas, E. (2015). Presence of mycotoxins in animal milk: A review. Food Control, 53, 163-176. https://doi.org/10.1016/j.foodcont.2015.01.020
Gacem, M. A., Gacem, H., Telli, A., & Khelil, A. O. E. H. (2020). Mycotoxins: Decontamination and nanocontrol methods. In Nanomycotoxicology (pp. 189-216). Elsevier. https://doi.org/https://doi.org/10.1016/B978-0-12-817998-7.00008-2
Grahovac, J., & Rončević, Z. (2021). Chapter 9 - Environmental impacts of the confectionary industry. In C. M. Galanakis (Ed.), Environmental Impact of Agro-Food Industry and Food Consumption (pp. 189-216). Academic Press. https://doi.org/https://doi.org/10.1016/B978-0-12-821363-6.00012-6
Greeff-Laubscher, M. R., Beukes, I., Marais, G. J., & Jacobs, K. (2020). Mycotoxin production by three different toxigenic fungi genera on formulated abalone feed and the effect of an aquatic environment on fumonisins. Mycology, 11(2), 105-117. https://doi.org/10.1080/21501203.2019.1604575
Groopman, J. D., Egner, P. A., Schulze, K. J., Wu, L. S.-F., Merrill, R., Mehra, S., . . . Gernand, A. (2014). Aflatoxin exposure during the first 1000 days of life in rural South Asia assessed by aflatoxin B1-lysine albumin biomarkers. Food and Chemical Toxicology, 74, 184-189. https://doi.org/10.1016/j.fct.2014.09.016
Groopman, J. D., & Wogan, G. N. (2016). Aflatoxin: A Global Public Health Problem. In B. Caballero, P. M. Finglas, & F. Toldrá (Eds.), Encyclopedia of Food and Health (pp. 68-72). Academic Press. https://doi.org/https://doi.org/10.1016/B978-0-12-384947-2.00015-5
Hassan, Z.-u., Al-Thani, R., Migheli, Q., & Jaoua, S. (2017). Detection of toxigenic mycobiota and mycotoxins in cereal feed market. Food Control, 84. https://doi.org/10.1016/j.foodcont.2017.08.032
Hassan, Z., Thani, R., F., A., Meer, S., Migheli, Q., & Jaoua, S. (2018). Co-occurrence of mycotoxins in commercial formula milk and cereal-based baby food on the Qatar market. Food Additives & Contaminants: Part B Surveillance, 11(3), 191-197. https://doi.org/10.1080/19393210.2018.1437785
Herrera, M., van Dam, R., Spanjer, M., de Stoppelaar, J., Mol, H., de Nijs, M., & López, P. (2017). Survey of moniliformin in wheat- and corn-based products using a straightforward analytical method. Mycotoxin Research, 33(4), 333-341. https://doi.org/10.1007/s12550-017-0287-9
Hickert, S., Bergmann, M., Ersen, S., Cramer, B., & Humpf, H. U. (2016). Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach. Mycotoxin Research, 32(1), 7-18. https://doi.org/10.1007/s12550-015-0233-7
Ho, P., & Vieira, M. M. C. (2007). Case studies in food safety and environmental health (Vol. 6). Springer Science & Business Media.
Iha, M. H., Mini, C. A., Okada, I. A., de Cássia Briganti, R., & Trucksess, M. W. (2017). The use of regenerated immunoaffinity columns for aflatoxins B1, B2, G1 and G2 in peanut confection. Journal of Chromatography A, 1483, 1-7. https://doi.org/10.1016/j.chroma.2016.12.040
Iqbal, S. Z., Rabbani, T., Asi, M. R., & Jinap, S. (2014). Assessment of aflatoxins, ochratoxin A and zearalenone in breakfast cereals. Food Chemistry, 157, 257-262. https://doi.org/10.1016/j.foodchem.2014.01.129
Jacobsen, B. J. (2014). Good agricultural and harvest practices to reduce mycotoxin contamination in wheat in temperate countries. Mycotoxin Reduction in Grain Chains, 209. https://doi.org/10.1002/9781118832790.ch14
Janik, E., Niemcewicz, M., Podogrocki, M., Ceremuga, M., Gorniak, L., Stela, M., & Bijak, M. (2021). The Existing Methods and Novel Approaches in Mycotoxins’ Detection. Molecules, 26(13). https://doi.org/10.3390/molecules26133981
Ji, X., Xiao, Y., Wang, W., Lyu, W., Wang, X., Li, Y., . . . Yang, H. (2022). Mycotoxins in cereal-based infant foods marketed in China: Occurrence and risk assessment. Food Control, 138, 108998. https://doi.org/10.1016/j.foodcont.2022.108998
Jiang, D., Chen, J., Li, F., Li, W., Yu, L., Zheng, F., & Wang, X. (2018). Deoxynivalenol and its acetyl derivatives in bread and biscuits in Shandong province of China. Food Additives & Contaminants Part B Surveillance, 11(1), 43-48. https://doi.org/10.1080/19393210.2017.1402824
Jimenez, M., Manez, M., & Hernandez, E. (1996). Influence of water activity and temperature on the production of zearalenone in corn by three Fusarium species. International Journal of Food Microbiology, 29(2-3), 417-421. https://doi.org/10.1016/0168-1605(95)00073-9
Jiménez-Ortega, L.A., Cuevas-Sánchez, B.Y., Patricio-Martínez, S., Albarrán-Rodríguez, E., González-Zamora, L.F., Reyes-Velazquez, W.P. (2021). Determinación de aflatoxinas totales (AFs) y AFB1 en dulces tipo “mazapán” de cacahuate y nuez comercializados en la zona metropolitana de Guadalajara, Jalisco. E-CUCBA (15), 21–32. https://doi.org/10.32870/e-cucba.v0i15.176
Junior, W. L., Trombete, F., Reis, L., Direito, G., Randow, A., & Saldanha, T. (2016). Aflatoxins intake from peanut candy marketed in Rio de Janeiro city, Brazil. International Food Research Journal, 23(2), 733.
Kamle, M., Mahato, D. K., Devi, S., Lee, K. E., Kang, S. G., & Kumar, P. (2019). Fumonisins: Impact on Agriculture, Food, and Human Health and Their Management Strategies. Toxins, 11(6). https://doi.org/10.3390/toxins11060328
Karlovsky, P., Suman, M., Berthiller, F., De Meester, J., Eisenbrand, G., Perrin, I., . . . Recker, T. (2016). Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Research, 32(4), 179-205. https://doi.org/10.1007/s12550-016-0257-7
Kaushik, G. (2015). Effect of processing on mycotoxin content in grains. Critical Reviews in Food Science and Nutrition, 55(12), 1672-1683. https://doi.org/10.1080/10408398.2012.701254
Khodaei, D., Javanmardi, F., & Khaneghah, A. M. (2021). The global overview of the occurrence of mycotoxins in cereals: a three-year survey. Current Opinion in Food Science, 39, 36-42. https://doi.org/10.1016/j.cofs.2020.12.012
Kirsch, J., Siltanen, C., Zhou, Q., Revzin, A., & Simonian, A. (2013). Biosensor technology: recent advances in threat agent detection and medicine. Chemical Society Reviews, 42(22), 8733-8768. https://doi.org/10.1039/C3CS60141B
Lasram, S., Oueslati, S., Valero, A., Marin, S., Ghorbel, A., & Sanchis, V. (2010). Water activity and temperature effects on fungal growth and ochratoxin A production by ochratoxigenic Aspergillus carbonarius isolated from Tunisian grapes. Journal of Food Science, 75(2), M89-M97. https://doi.org/10.1111/j.1750-3841.2009.01484.x
Li, R., Wang, X., Zhou, T., Yang, D., Wang, Q., & Zhou, Y. (2014). Occurrence of four mycotoxins in cereal and oil products in Yangtze Delta region of China and their food safety risks. Food Control, 35(1), 117-122. https://doi.org/10.1016/j.foodcont.2013.06.042
Liu, J., Sun, L., Zhang, N., Zhang, J., Guo, J., Li, C., . . . Qi, D. (2016). Effects of nutrients in substrates of different grains on aflatoxin B1 production by Aspergillus flavus. BioMed Research International, 2016. https://doi.org/10.1155/2016/7232858
Logrieco, A. F., Miller, J. D., Eskola, M., Krska, R., Ayalew, A., Bandyopadhyay, R.,... De Saeger, S. (2018). The mycotox charter: increasing awareness of, and concerted action for, minimizing mycotoxin exposure worldwide. Toxins, 10(4), 149. https://doi.org/10.3390/toxins10040149
Lopes, P., Sobral, M.M.C., Lopes, G.R., Martins, Z.E., Passos, C.P., Petronilho, S., & Ferreira, I. M.P.L.V.O. (2023). Mycotoxins’ Prevalence in Food Industry By-Products: A Systematic Review. Toxins, 15(4), 249. https://doi.org/10.3390/toxins15040249
Luo, S., Du, H., Kebede, H., Liu, Y., & Xing, F. (2021). Contamination status of major mycotoxins in agricultural products and foodstuffs in Europe. Food Control, 127, 108120. https://doi.org/10.1016/j.foodcont.2021.108120
Lyagin, I., & Efremenko, E. (2019). Enzymes for detoxification of various mycotoxins: Origins and mechanisms of catalytic action. Molecules, 24(13), 2362. https://doi.org/10.3390/molecules24132362
Mafe, A. N., & Busselberg, D. (2025). Mycotoxins in Food: Cancer Risks and Strategies for Control. Foods, 12(21), 3502. https://doi.org/10.3390/foods13213502
Magan, N., & Aldred, D. (2007). Post-harvest control strategies: minimizing mycotoxins in the food chain. International Journal of Food Microbiology, 119(1-2), 131-139. https://doi.org/10.1016/j.ijfoodmicro.2007.07.034
Magan, N., Medina, A., & Aldred, D. (2011). Possible climate‐change effects on mycotoxin contamination of food crops pre‐and postharvest. Plant Pathology, 60(1), 150-163. https://doi.org/10.1111/j.1365-3059.2010.02412.x
Magnussen, A., & Parsi, M. A. (2013). Aflatoxins, hepatocellular carcinoma and public health. World Journal of Gastroenterology: WJG, 19(10), 1508. https://doi.org/10.3748/wjg.v19.i10.1508
Majeed, M., Kadmi, Y., Khan, M., & Shariati, M. A. (2017). Assessment of Ochratoxin A in Commercial Corn and Wheat Products. Current Nutrition & Food Science. https://doi.org/10.2174/1573401313666170330155823
Man, Y., Liang, G., Li, A., & Pan, L. (2017). Recent advances in mycotoxin determination for food monitoring via microchip. Toxins, 9(10), 324. https://doi.org/10.3390/toxins9100324
Mannaa, M., & Kim, K. D. (2017). Influence of temperature and water activity on deleterious fungi and mycotoxin production during grain storage. Mycobiology, 45(4), 240-254. https://doi.org/10.5941/MYCO.2017.45.4.240
Martins, C., Assunção, R., Cunha, S. C., Fernandes, J. O., Jager, A., Petta, T.,... Alvito, P. (2018). Assessment of Multiple Mycotoxins in Breakfast Cereals Available in the Portuguese Market. Food Chemistry, 239, 132-140. https://doi.org/10.1016/j.foodchem.2017.06.088
Matumba, L., Namaumbo, S., Ngoma, T., Meleke, N., De Boevre, M., Logrieco, A. F., & De Saeger, S. (2021). Five keys to prevention and control of mycotoxins in grains: A proposal. Global Food Security, 30, 100562. https://doi.org/10.1016/j.gfs.2021.100562
Mazumder, P. M., & Sasmal, D. (2001). Mycotoxins–limits and regulations. Ancient science of life, 20(3), 1.
Meerpoel, C., Vidal, A., Andjelkovic, M., De Boevre, M., Tangni, E. K., Huybrechts, B.,… De Saeger, S. (2021). Dietary exposure assessment and risk characterization of citrinin and ochratoxin A in Belgium. Food and Chemical Toxicology, 147, 111914. https://doi.org/10.1016/j.fct.2020.111914
Milani, J. (2013). Ecological conditions affecting mycotoxin production in cereals: a review. Veterinarni Medicina, 58(8). https://doi.org/10.17221/6979-VETMED
Milićević, D., Nastasijevic, I., & Petrovic, Z. (2016). Mycotoxin in the food supply chain—implications for public health programs. Journal of Environmental Science and Health, Part C, 34(4), 293-319. https://doi.org/10.1080/10590501.2016.1236607.
Miliordos, D.E., Baliota, G.V., Athanassiou, C.G., & Natskoulis. (2025). Review on the Occurrence of Mycotoxigenic Fungi in Dried Fruits and the Role of Stored-Product Insects. Toxins, 17(7), 313. https://doi.org/10.3390/toxins17070313
Mitchell, N. J., Chen, C., Palumbo, J. D., Bianchini, A., Cappozzo, J., Stratton, J.,… Wu, F. (2017). A risk assessment of dietary Ochratoxin A in the United States. Food and Chemical Toxicology, 100, 265-273. https://doi.org/10.1016/j.fct.2016.12.037
Molina-Pintor, I. B., Ruíz-Arias, M. A., Guerrero-Flores, M. C., Rojas-García, A. E., Barrón-Vivanco, B. S., Medina-Díaz, I. M., . . . González-Arias, C. A. (2021). Preliminary survey of the occurrence of mycotoxins in cereals and estimated exposure in a northwestern region of Mexico. International Journal of Environmental Health Research, 1-15. https://doi.org/10.1080/09603123.2021.1953447
Mollay, C., Kimanya, M., Kassim, N., & Stoltzfus, R. (2022). Main complementary food ingredients contributing to aflatoxin exposure to infants and young children in Kongwa, Tanzania. Food Control, 135, 108709. https://doi.org/10.1016/j.foodcont.2021.108709
Mousavi-Khaneghah, A., Eş, I., Raeisi, S., & Fakhri, Y. (2018). Aflatoxins in cereals: State of the art. Journal of Food Safety, 38(6), e12532. https://doi.org/10.1111/jfs.12532
Mupunga, I., Mngqawa, P., & Katerere, D. R. (2017). Peanuts, Aflatoxins and Undernutrition in Children in Sub-Saharan Africa. Nutrients, 9(12). https://doi.org/10.3390/nu9121287
Naz, N., Kashif, A., Kanwal, K., & Ajaz, H. (2017). Incidence of mycotoxins in local and branded samples of chocolates marketed in Pakistan. Journal of Food Quality, 2017. https://doi.org/10.1155/2017/1947871
Niens, C., Strack, M., & Marggraf, R. (2014). Parental risk perception of mycotoxins and risk reduction behaviour. British Food Journal, 116(6), 1014-1030. https://doi.org/10.1108/BFJ-10-2012-0260
Norma Oficial Mexicana. (2009). NOM-247-SSA1-2008, Productos y servicios. Cereales y sus productos. Cereales, harinas de cereales, sémolas o semolinas. Alimentos a base de: cereales, semillas comestibles, de harinas, sémolas o semolinas o sus mezclas. Productos de panificación. Disposiciones y especificaciones sanitarias y nutrimentales. Métodos de prueba. https://dof.gob.mx/nota_detalle.php?codigo=5100356&fecha=27/07/2009#gsc.tab=0
Norma Oficial Mexicana. (2002). NOM-188-SSA1-2002, Productos y Servicios. Control de aflatoxinas en cereales para consumo humano y animal. Especificaciones sanitarias. https://salud.gob.mx/unidades/cdi/nom/188ssa12.html
Norma Oficial Mexicana. (2022). PROYECTO de la Norma Oficial Mexicana PROY-NOM-217-SSA1-2002, Productos y servicios. Productos de confitería. Especificaciones sanitarias. Métodos de prueba. https://www.dof.gob.mx/nota_detalle.php?codigo=691942&fecha=15/08/2003#gsc.tab=0
Norma Oficial Mexicana. (2013). NOM-186-SSA1/SCFI-2013, Cacao, chocolate y productos similares, y derivados del cacao. Especificaciones sanitarias. Denominación comercial. Métodos de prueba. https://www.dof.gob.mx/nota_detalle.php?codigo=5332832&fecha=17/02/2014#gsc.tab=0
Noroozi, R., Kobarfard, F., Rezaei, M., Ayatollahi, S. A., Paimard, G., Eslamizad, S.,… Sadeghi, E. (2022). Occurrence and exposure assessment of aflatoxin B1 in Iranian breads and wheat-based products considering effects of traditional processing. Food Control, 138, 108985. https://doi.org/10.1016/j.foodcont.2022.108985
Ojuri, O. T., Ezekiel, C. N., Eskola, M. K., Šarkanj, B., Babalola, A. D., Sulyok, M.,…Krska, R. (2019). Mycotoxin co-exposures in infants and young children consuming household- and industrially-processed complementary foods in Nigeria and risk management advice. Food Control, 98, 312-322. https://doi.org/10.1016/j.foodcont.2018.11.049
Omotayo, O. P., Omotayo, A. O., Mwanza, M., & Babalola, O. O. (2019). Prevalence of mycotoxins and their consequences on human health. Toxicological research, 35(1), 1-7. https://doi.org/10.5487/TR.2019.35.1.001
Onyeke, C. C. (2020). Review of mycotoxins in foods in Nigeria. Food Control, 118, 107376. https://doi.org/10.1016/j.foodcont.2020.107376
Ostry, V., Malir, F., Toman, J., & Grosse, Y. (2017). Mycotoxins as human carcinogens—the IARC Monographs classification. Mycotoxin research, 33(1), 65-73. https://doi.org/10.1007/s12550-016-0265-7
Oueslati, S. (2020). Multiple Mycotoxin Determination on Tunisian Cereals-Based Food and Evaluation of the Population Exposure. Food analytical methods 13(6), 1271-1281-2020. https://doi.org/10.1007/s12161-020-01737-z
Peraica, M., & Rašić, D. (2012). The impact of mycotoxicoses on human history. Archives of Industrial Hygiene and Toxicology, 63(4). https://doi.org/10.2478/10004-1254-63-2012-2259
Peraica, M., Richter, D., & Rašić, D. (2014). Mycotoxicoses in children. Arhiv za Higijenu Rada i Toksikologiju, 65, 347-363. https://doi.org/10.2478/10004-1254-65-2014-2557
Pereira, V., Fernandes, J., & Cunha, S. (2014). Mycotoxins in cereals and related foodstuffs: A review on occurrence and recent methods of analysis. Trends in Food Science & Technology, 36(2), 96-136. https://doi.org/10.1016/j.tifs.2014.01.005
Ponce-García, N., Serna-Saldivar, S. O., & Garcia-Lara, S. (2018). Fumonisins and their analogues in contaminated corn and its processed foods–a review. Food Additives & Contaminants: Part A, 35(11), 2183-2203. https://doi.org/10.1080/19440049.2018.1502476
Porto, Y. D., Trombete, F. M., Freitas-Silva, O., De Castro, I. M., Direito, G. M., & Ascheri, J. L. R. (2019). Gaseous ozonation to reduce aflatoxins levels and microbial contamination in corn grits. Microorganisms, 7(8), 220. https://doi.org/10.3390/microorganisms7080220
Pralatnet, S., Poapolathep, S., Giorgi, M., Imsilp, K., Kumagai, S., & Poapolathep, A. (2016). Survey of Deoxynivalenol and Aflatoxin B1 in Instant Noodles and Bread Consumed in Thailand by Using Liquid Chromatography–Tandem Mass Spectrometry. Journal of Food Protection, 79, 1269-1272. https://doi.org/10.4315/0362-028X.JFP-15-510
Quiles, J. M., Saladino, F., Mañes, J., Fernández-Franzón, M., & Meca, G. (2016). Occurrence of mycotoxins in refrigerated pizza dough and risk assessment of exposure for the Spanish population. Food and Chemical Toxicology, 94, 19-24. https://doi.org/10.1016/j.fct.2016.05.011
Ramirez, M. L., Chulze, S., & Magan, N. (2006). Temperature and water activity effects on growth and temporal deoxynivalenol production by two Argentinean strains of Fusarium graminearum on irradiated wheat grain. International Journal of Food Microbiology, 106(3), 291-296. https://doi.org/10.1016/j.ijfoodmicro.2005.09.004.
Reddy, K., Salleh, B., Saad, B., Abbas, H., Abel, C., & Shier, W. (2010). An overview of mycotoxin contamination in foods and its implications for human health. Toxin reviews, 29(1), 3-26. https://doi.org/10.3109/15569541003598553
Ritter, A. C., Hoeltz, M., & Noll, I. B. (2011). Toxigenic potential of Aspergillus flavus tested in different culture conditions. Food Science and Technology, 31(3), 623-628. https://doi.org/10.1590/S0101-20612011000300011
Rubert, J., Fapohunda, S., Soler, C., Ezekiel, C., Mañes, J., & Kayode, F. (2013). A survey of mycotoxins in random street-vended snacks from Lagos, Nigeria, using QuEChERS-HPLC-MS/MS. Food Control, 32(2), 673-677. https://doi.org/10.1016/j.foodcont.2013.01.017
Saladino, F., Quiles, J. M., Mañes, J., Fernández-Franzón, M., Luciano, F. B., & Meca, G. (2017). Dietary exposure to mycotoxins through the consumption of commercial bread loaf in Valencia, Spain. LWT, 75, 697-701. https://doi.org/10.1016/j.lwt.2016.10.029
Sánchez-Hervás, M., Gil, J., Bisbal, F., Ramón, D., & Martínez-Culebras, P. (2008). Mycobiota and mycotoxin producing fungi from cocoa beans. International Journal of Food Microbiology, 125(3), 336-340. https://doi.org/10.1016/j.ijfoodmicro.2008.04.021.
Santos, A. O., Vaz, A., Rodrigues, P., Veloso, A. C., Venâncio, A., & Peres, A. M. (2019). Thin films sensor devices for mycotoxins detection in foods: Applications and challenges. Chemosensors, 7(1), 3. https://doi.org/10.3390/chemosensors7010003
Sarmast, E., Fallah, A. A., Jafari, T., & Mousavi Khaneghah, A. (2021). Occurrence and fate of mycotoxins in cereals and cereal-based products: a narrative review of systematic reviews and meta-analyses studies. Current Opinion in Food Science, 39, 68-75. https://doi.org/10.1016/j.cofs.2020.12.013
Savi, G. D., Piacentini, K. C., Tibola, C. S., Santos, K., Sousa Maria, G., & Scussel, V. M. (2016). Deoxynivalenol in the wheat milling process and wheat-based products and daily intake estimates for the Southern Brazilian population. Food Control, 62, 231-236. https://doi.org/10.1016/j.foodcont.2015.10.029
Shanakhat, H., Sorrentino, A., Raiola, A., Romano, A., Masi, P., & Cavella, S. (2018). Current methods for mycotoxins analysis and innovative strategies for their reduction in cereals: an overview. Journal of the Science of Food and Agriculture, 98(11), 4003-4013. https://doi.org/10.1002/jsfa.8933
Shephard, G. S. (2016). Current status of mycotoxin analysis: a critical review. Journal of AOAC International, 99(4), 842-848. https://doi.org/10.5740/jaoacint.16-0111
Shirima, C. P., Kimanya, M. E., Routledge, M. N., Srey, C., Kinabo, J. L., Humpf, H.-U., . . . Gong, Y. Y. (2015). A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania. Environmental Health Perspectives, 123(2), 173-178. https://doi.org/10.1289/ehp.1408097
Shkembi, X., Svobodova, M., Skouridou, V., Bashammakh, A. S., Alyoubi, A. O., & O'Sullivan, C. K. (2022). Aptasensors for mycotoxin detection: A review. Analytical Biochemistry, 644, 114156. https://doi.org/10.1016/j.ab.2021.114156
Singh, S. D., & Chuturgoon, A. A. (2017). A comparison of mycotoxin contamination of premium and grocery brands of pelleted cat food in South Africa. Journal of the South African Veterinary Association, 88(1), 1-6. 10.4102/jsava.v88i0.1480.
Smith, M.-C., Madec, S., Coton, E., & Hymery, N. (2016). Natural co-occurrence of mycotoxins in foods and feeds and their in vitro combined toxicological effects. Toxins, 8(4), 94. https://doi.org/10.3390/toxins8040094
Soares, R., Novo, P., Azevedo, A., Fernandes, P., Chu, V., Conde, J., & Aires-Barros, M. (2014). Aqueous two-phase systems for enhancing immunoassay sensitivity: Simultaneous concentration of mycotoxins and neutralization of matrix interference. Journal of Chromatography A, 1361, 67-76. https://doi.org/10.1016/j.chroma.2014.08.007
Souza, G. F. d., Mossini, S. A. G., Arrotéia, C. C., Kemmelmeier, C., & Machinski Junior, M. (2014). Evaluation of the mycoflora and aflatoxins from the pre-harvest to storage of peanuts: a case study. Acta Scientiarum. Agronomy, 36(1), 27-33. https://doi.org/10.4025/actasciagron.v36i1.16972
Stanciu, O., Juan, C., Miere, D., Loghin, F., & Mañes, J. (2017). Analysis of enniatins and beauvericin by LC-MS/MS in wheat-based products. CyTA - Journal of Food, 15(3), 433-440. https://doi.org/10.1080/19476337.2017.1288661
Stroka, J., & Maragos, C. (2016). Challenges in the analysis of multiple mycotoxins. World Mycotoxin Journal, 9(5), 847-861. https://doi.org/10.3920/WMJ2016.2038
Taborda, B., Santos, A. P. M., Costa, M. T., Mendes, M. M., Lopes de Andrade, V., & Mateus, L. (2022). Contribution of cereals and cows’ milk consumption to the exposure to mycotoxins: a study with Portuguese children. Food Additives & Contaminants: Part A, 39(3), 588-598. https://doi.org/10.1080/19440049.2021.2010811
Taheur, F. B., Kouidhi, B., Al Qurashi, Y. M. A., Salah-Abbès, J. B., & Chaieb, K. (2019). Biotechnology of mycotoxins detoxification using microorganisms and enzymes. Toxicon, 160, 12-22. https://doi.org/10.1016/j.toxicon.2019.02.001
Tola, M., & Kebede, B. (2016). Occurrence, importance and control of mycotoxins: A review. Cogent Food & Agriculture, 2(1), 1191103. https://doi.org/10.1080/23311932.2016.1191103
Van der Fels-Klerx, H., Liu, C., & Battilani, P. (2016). Modelling climate change impacts on mycotoxin contamination. World Mycotoxin Journal, 9(5), 717-726. https://doi.org/10.3920/WMJ2016.2066
van Egmond, H. P., Schothorst, R. C., & Jonker, M. A. (2007). Regulations relating to mycotoxins in food. Analytical and bioanalytical chemistry, 389(1), 147-157. https://doi.org/10.1007/s00216-007-1317-9
Vartolomei, A., Vlase, L., Cuciureanu, M., Cuciureanu, R., & Popa, D.-S. (2014). Determination of ochratoxin a in food by LC-MS/MS. Farmacia, 62, 287-298.
Venturini, G., Assante, G., & Vercesi, A. (2011). Fusarium verticillioides contamination patterns in Northern Italian maize during the growing season. Phytopathologia Mediterranea, 50(1), 110-120. https://doi.org/10.14601/Phytopathol_Mediterr-8680
Visser, M. E., Ezekiel, C. N., Schoonees, A., Esterhuizen, T. M., Randall, N., & Naude, C. E. (2019). Agricultural and nutritional educational interventions for reducing aflatoxin exposure to improve infant and child growth in low‐and middle‐income countries. The Cochrane Database of Systematic Reviews, 2019(7). https://doi.org/10.1002/14651858.CD013376.pub2
Wagacha, J., & Muthomi, J. (2008). Mycotoxin problem in Africa: current status, implications to food safety and health and possible management strategies. International Journal of Food Microbiology, 124(1), 1-12. https://doi.org/10.1016/j.ijfoodmicro.2008.01.008
Wall Martínez, H., Alejandra, R.-M., Wesolek, N., Brabet, C., Noel, D., Rodriguez-Jimenes, G., . . . Roudot, A.-C. (2019). Risk assessment of exposure to mycotoxins (aflatoxins and fumonisins) through corn tortilla intake in Veracruz City (Mexico). Food Additives & Contaminants: Part A, 36, 1-11. https://doi.org/10.1080/19440049.2019.1588997
Wan, J., Chen, B., & Rao, J. (2020). Occurrence and preventive strategies to control mycotoxins in cereal‐based food. Comprehensive reviews in food science and food safety, 19. https://doi.org/10.1111/1541-4337.12546
Wang, L., Wu, J., Liu, Z., Shi, Y., Liu, J., Xu, X., . . . Deng, Y. (2019). Aflatoxin B1 degradation and detoxification by Escherichia coli CG1061 isolated from chicken cecum. Frontiers in Pharmacology, 9, 1548. https://doi.org/10.3389/fphar.2018.01548
Wang, X. (2020). The degradation of Alternaria mycotoxins by dielectric barrier discharge cold plasma. Food Control, v. 117, pp. 107333--102020 v.107117. https://doi.org/10.1016/j.foodcont.2020.107333
Wawrzyniak, J., & Waśkiewicz, A. (2014). Ochratoxin A and citrinin production by Penicillium verrucosum on cereal solid substrates. Food Additives & Contaminants: Part A, 31(1), 139-148. https://doi.org/10.1080/19440049.2013.861933
Wild, C., Miller, J., & Groopman, J. (2015). Effects of aflatoxins on aflatoxicosis and liver cancer. Mycotoxin Control in Low-and Middle-Income Countries. International Agency for Research on Cancer.
Winter, G., & Pereg, L. (2019). A review on the relation between soil and mycotoxins: Effect of aflatoxin on field, food and finance. European Journal of Soil Science, 70(4), 882-897. https://doi.org/10.1111/ejss.12813
Wright, C. M. (2017). Uses and abuses of snack foods in child health. Archives of disease in childhood - Education & Practice Edition, 102(6), 293. https://doi.org/10.1136/archdischild-2017-313471
Wu, F., Bhatnagar, D., Bui-Klimke, T., Carbone, I., Hellmich, R., Munkvold, G., . . . Takle, E. (2011). Climate change impacts on mycotoxin risks in US maize. World Mycotoxin Journal, 4(1), 79-93. https://doi.org/10.3920/WMJ2010.1246
Wu, F., & Mitchell, N. (2016). How climate change and regulations can affect the economics of mycotoxins. World Mycotoxin Journal, 9(5), 653-663. https://doi.org/10.3920/WMJ2015.2015
Zhang, K., Flannery, B. M., Oles, C. J., & Adeuya, A. (2018). Mycotoxins in infant/toddler foods and breakfast cereals in the US retail market. Food Additives & Contaminants Part B Surveillance, 11(3), 183-190. https://doi.org/10.1080/19393210.2018.1451397
Zhao, K., Shao, B., Yang, D., Li, F., & Zhu, J. (2015). Natural Occurrence of Alternaria Toxins in Wheat-Based Products and Their Dietary Exposure in China. PLoS One, 10(6), e0132019. https://doi.org/10.1371/journal.pone.0132019
Zhao, Y., Wang, Q., Huang, J., Ma, L., Chen, Z., & Wang, F. (2018). Aflatoxin B1 and sterigmatocystin in wheat and wheat products from supermarkets in China. Food Additives & Contaminants: Part B, 11(1), 9-14. https://doi.org/10.1080/19393210.2017.1388295

Revista Bio Ciencias por Universidad Autónoma de Nayarit se encuentra bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivadas 4.0 Unported.
Basada en una obra en http://biociencias.uan.edu.mx/.
Permisos que vayan más allá de lo cubierto por esta licencia pueden encontrarse en http://editorial.uan.edu.mx/index.php/BIOCIENCIAS.licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional