Abstract
Case of a 54-year-old patient who developed a severe, generalized skin reaction known as toxic epidermal necrolysis (TEN) after starting treatment with allopurinol for gout. The aim of this report is to describe the clinical presentation, diagnosis, and management of this rare but potentially fatal adverse event. The patient experienced an extensive skin rash, blisters, and skin detachment, affecting approximately 70% of their body. Additionally, they presented with systemic complications such as kidney failure and electrolyte imbalances. The diagnosis was confirmed by clinical findings, histopathology, and the temporal relationship with medication administration. Treatment focused on life support measures, pain control, and infection prevention, as well as immediate discontinuation of allopurinol. Despite treatment, the patient's recovery was slow and complicated.
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