Abstract
Bovine tuberculosis is an infectious-contagious disease that causes severe direct or indirect economic losses, such as limitations in the movement and trade of animals and their products. In Mexico, the control of the disease is based on “test and slaughter”, where reactive animals are sent to slaughterhouses. An alternative for control is vaccination with BCG, which has already been tested under experimental conditions, demonstrating an efficacy of more than 60%. However, there is doubt that environmental mycobacteria mask this efficacy. The objective of this work was to rule out the presence of environmental mycobacteria through the detection of IFN-γ in response to the PPD-bovis and PPD-avium antigens. From blood samples from animals vaccinated and not vaccinated with BCG-Phipps and subsequently challenged with a field strain of M. bovis, a general average IFN-γ response was obtained, which was significantly higher when the stimulus was made with PPD-bovis than with PPD-avium, so we can conclude that environmental mycobacteria have no influence on the response to vaccination.
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